EBV Latent Membrane Protein 1 Is a Negative Regulator of TLR9

EBV latent membrane protein 1 is a negative regulator of TLR9.

EBV infects most of the human population and is associated with a number of human diseases including cancers. Moreover, evasion of the immune system and chronic infection is an essential step for EBV-associated diseases. In this paper, we show that EBV can alter the regulation and expression of TLRs, the key effector molecules of the innate immune response. EBV infection of human primary B cell...

Negative Regulator of TLR 9 EBV Latent Membrane Protein 1 Is a

Negative Regulator of TLR 9 EBV Latent Membrane Protein

Negative Regulator of TLR 9 EBV Latent Membrane Protein 1 Is

EBV latent membrane protein-1 protects B cells from apoptosis by inhibition of BAX.

Latent membrane protein 1 (LMP-1) of Epstein-Barr virus (EBV) promotes tumorigenesis by inhibiting apoptosis. We show that an important antiapoptotic activity of LMP-1 is the inhibition of Bcl2-associated protein X (Bax), a potent proapoptotic protein. BAX expression was regulated by LMP-1 activation of nuclear factor kappaB (NF-kappaB) via the C-terminal activation region 1 (CTAR-1) and CTAR-2...